Addressing Health Disparities among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional) | PAR 21 081

Opportunity Information: Apply for PAR 21 081

The NIH funding opportunity PAR-21-081, titled "Addressing Health Disparities among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional)," supports research projects that develop, test, and implement interventions aimed at improving health outcomes for immigrant populations in the United States. The central focus is on building evidence for strategies that both strengthen existing health advantages seen in some immigrant communities and reduce persistent health disparities that can arise or worsen after migration. Because it uses the R01 mechanism and notes that clinical trials are optional, applicants can propose either clinical trial research or non-trial intervention research, as long as the work is structured around rigorous design and meaningful evaluation of interventions intended to improve health and equity among immigrants.

This opportunity is offered by the National Institutes of Health under a discretionary grant mechanism, with activity categories spanning education, environment, and health. It is associated with multiple CFDA numbers (93.113, 93.273, 93.307, 93.393, 93.399), indicating that it may align with several NIH institutes or programs that share interests in minority health, behavioral and social determinants, prevention, and disparities research. The overarching goal is practical and intervention-oriented: applicants are expected to move beyond describing disparities to actually testing solutions that can be implemented in real settings and that are responsive to the lived experiences and structural barriers faced by immigrant groups.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs (Asian American and Native American Pacific Islander Serving Institutions), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. This broad eligibility reflects an emphasis on partnerships and research capacity across institutions that are closely connected to immigrant communities and to underserved populations more generally.

There are important limits regarding foreign involvement. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply as the primary applicant. In addition, non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed when they meet NIH definitions and requirements in the NIH Grants Policy Statement. In practical terms, this usually means the main applicant institution must be U.S.-based, but limited parts of the research can involve foreign components if they are well-justified and compliant with NIH policy, such as leveraging specialized expertise or conducting certain analyses, while still keeping the core project centered on immigrant health within the United States.

The original closing date listed for this opportunity is January 7, 2023, and the opportunity was created on November 17, 2020. The listing does not provide an award ceiling or an expected number of awards in the provided data, so applicants typically would need to consult the full NIH notice and any linked institute-specific guidance to understand budget expectations, project periods, and likely funding levels. Overall, this R01 opportunity is geared toward generating actionable, scalable evidence on intervention approaches that can reduce inequities affecting immigrant populations in the U.S., using rigorous research designs and strong implementation plans that fit real-world community and service settings.

• The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Addressing Health Disparities among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.273, 93.307, 93.393, 93.399.
• This funding opportunity was created on 2020-11-17.
• Applicants must submit their applications by 2023-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 21 081

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