Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) | PAS 19 105

Opportunity Information: Apply for PAS 19 105

The Stimulating Hematology Investigation: New Endeavors (SHINE) funding opportunity (PAS 19-105) is an NIH R01 program designed to grow and refresh the nonmalignant hematology research portfolio by attracting innovative, high-quality investigator-initiated projects. Its focus is on basic and early translational research that advances understanding of blood and blood-forming systems in ways that align with the missions of three participating NIH Institutes: the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). A key feature of SHINE is that it targets emerging, cutting-edge topics in the field; those specific topic priorities are not fixed permanently but are updated over time, typically on an annual basis, through notices in the NIH Guide to Grants and Contracts and then linked back to the FOA. In practice, this means applicants are expected to pay attention to the most current set of highlighted scientific areas when shaping their R01 aims, while still proposing strong, hypothesis-driven work that fits within nonmalignant hematology and the participating Institutes priorities.

This FOA uses the R01 research project grant mechanism and explicitly does not allow clinical trials. That restriction generally means applications should avoid study designs in which human participants are prospectively assigned to an intervention to assess health-related outcomes. The intent is to support foundational and early translational work, such as mechanistic studies, model-system research, development or refinement of experimental approaches, and other preclinical or early-stage translational investigations that can eventually enable later clinical evaluation through other mechanisms. The program is positioned for investigators proposing new directions or novel approaches within nonmalignant hematology, with an emphasis on innovation and strong scientific rationale rather than incremental extensions of well-established lines of work.

Eligibility is broad and includes many types of domestic organizations and governments. Eligible applicants listed include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education when specified); for-profit organizations (other than small businesses); and small businesses. The FOA also highlights additional eligible applicant types that NIH often emphasizes for broad participation, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions.

At the same time, there are clear limits on non-U.S. participation. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed, which typically means a U.S.-based applicant may include certain well-justified project elements carried out in a foreign location when they are essential to the project and meet NIH policy requirements.

From an administrative standpoint, SHINE is a discretionary grant opportunity administered by the National Institutes of Health, with an activity category aligned to health (and categorized in the source data under Food and Nutrition, Health) and CFDA numbers 93.839, 93.847, and 93.866. The opportunity was created on 2018-12-17, and the source record lists an original closing date of 2021-12-22. The award ceiling and expected number of awards are not specified in the provided listing, which is common for some NIH FOAs where budgets are generally governed by R01 norms, Institute policies, and the needs of the proposed work rather than a single fixed cap in the summary record.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839, 93.847, 93.866.
• This funding opportunity was created on 2018-12-17.
• Applicants must submit their applications by 2021-12-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAS 19 105

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