Opportunity Information: Apply for RFA AI 27 012
The National Institutes of Health (NIH), through the National Institute of Allergy and Infectious Diseases (NIAID), is offering a discretionary grant opportunity titled "Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)" under Funding Opportunity Number RFA-AI-27-012. The program is designed to create a set of highly collaborative, multidisciplinary research centers focused on advancing translational and clinical research that directly supports development of a vaccine for coccidioidomycosis (Valley fever). This initiative aligns with NIAID's Strategic Plan for Research to Develop a Valley Fever Vaccine, with the expectation that funded teams will coordinate expertise and resources in a center-style structure to move the field toward a viable vaccine candidate and the evidence base needed to support it.
The funding mechanism is a P01 research program project grant, which typically supports a coordinated group of related projects under a unified scientific theme, often with shared cores and strong integration across components. While the work is intended to be translational and clinical in orientation, the announcement explicitly states "Clinical Trial Not Allowed," meaning applicants should not propose NIH-defined clinical trials within this award. In practice, that generally steers applicants toward preclinical-to-clinical translational activities, clinical research that does not meet the NIH definition of a clinical trial, and other vaccine-enabling studies that can strengthen the pipeline without conducting interventional trials under this particular award.
NIH anticipates making about four awards, with an award ceiling listed at $1,200,000 (as provided in the opportunity data). The original application closing date is July 9, 2026, and the opportunity was created on May 4, 2026. The CFDA (Assistance Listing) number associated with this opportunity is 93.855, which corresponds to allergy and infectious diseases research support under NIAID.
A wide range of U.S.-based organizations are eligible to apply. Eligible applicants include state, county, city or township, and special district governments; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities as permitted under NIH policy and the NOFO's Section III. This broad eligibility signals that NIAID is aiming to bring together academic groups, research institutes, public entities, and potentially industry partners (including for-profit entities) to build the kind of multidisciplinary teams typically needed for vaccine development.
The opportunity includes specific restrictions and allowances regarding international participation. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the primary applicant, and non-domestic components of U.S. organizations are also not eligible to apply as applicant components. However, "foreign components" as defined in the NIH Grants Policy Statement are allowed, which generally means a U.S. applicant organization may include certain well-justified, discrete elements of the project that are performed outside the United States, subject to NIH's foreign component rules and approvals. This structure allows access to unique expertise, materials, or settings abroad when scientifically necessary, while keeping award leadership and organizational responsibility within eligible U.S. entities.
Overall, this NOFO is aimed at building coordinated research centers that can accelerate Valley fever vaccine progress by integrating multiple disciplines and project elements into a single collaborative framework. Applicants should be prepared to propose an organized center-like program with strong internal coordination, clear translational relevance to vaccine development, and activities that remain outside the scope of prohibited clinical trials, while also meeting NIH requirements for eligibility and any foreign component involvement. For the most precise requirements, expectations, and review criteria, prospective applicants would need to consult the full NOFO text, especially the detailed eligibility section referenced in the description.Apply for RFA AI 27 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2026-05-04.
- Applicants must submit their applications by 2026-07-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,200,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)."
What is the Funding Opportunity Number (NOFO number)?
The Funding Opportunity Number is RFA-AI-27-012.
Which NIH Institute is offering this grant?
The National Institutes of Health (NIH), through the National Institute of Allergy and Infectious Diseases (NIAID), is offering this grant opportunity.
What scientific area does this program focus on?
This program focuses on coccidioidomycosis (Valley fever), specifically research that directly supports development of a vaccine for coccidioidomycosis.
What is the main purpose of the program?
The program is designed to create a set of highly collaborative, multidisciplinary research centers that advance translational and clinical research in ways that directly support Valley fever vaccine development and strengthen the evidence base needed to support a viable vaccine candidate.
How does this opportunity fit within NIAID priorities?
This initiative aligns with NIAID's Strategic Plan for Research to Develop a Valley Fever Vaccine, with an expectation that funded teams will coordinate expertise and resources to move the field toward a viable vaccine candidate.
What grant mechanism is being used?
The funding mechanism is a P01 research program project grant.
What does a P01 "research program project grant" generally support?
A P01 typically supports a coordinated group of related projects organized under a unified scientific theme, often including shared cores and strong integration across the different components.
What kind of organizational structure is NIH expecting for proposed work?
The NOFO is aimed at creating center-style programs. Applicants should be prepared to propose an organized, collaborative research center structure with strong internal coordination and clear integration across projects and resources.
Is this opportunity intended to support translational and clinical research?
Yes. The work is described as translational and clinical in orientation, with the key emphasis that the research must directly support vaccine development for coccidioidomycosis.
Are clinical trials allowed under this opportunity?
No. The announcement explicitly states "Clinical Trial Not Allowed," meaning applicants should not propose NIH-defined clinical trials within this award.
What does "Clinical Trial Not Allowed" mean in practice for applicants?
Based on the description provided, it generally steers applicants toward preclinical-to-clinical translational activities, clinical research that does not meet the NIH definition of a clinical trial, and other vaccine-enabling studies that strengthen the pipeline without conducting interventional trials under this award.
How many awards does NIH anticipate making?
NIH anticipates making about four awards.
What is the award ceiling for this opportunity?
The award ceiling listed in the opportunity data is $1,200,000.
When is the application due?
The original application closing date is July 9, 2026.
When was this opportunity created?
The opportunity was created on May 4, 2026.
What is the CFDA/Assistance Listing number for this opportunity?
The associated Assistance Listing (CFDA) number is 93.855, which corresponds to allergy and infectious diseases research support under NIAID.
Who is eligible to apply?
A wide range of U.S.-based organizations are eligible, including state, county, city or township, and special district governments; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities as permitted under NIH policy and the NOFO's Section III.
Can for-profit organizations apply?
Yes. The eligibility list includes for-profit organizations other than small businesses as well as small businesses.
Can nonprofit organizations apply even if they do not have 501(c)(3) status?
Yes. The eligibility list includes nonprofits with and without 501(c)(3) status (other than institutions of higher education).
Can universities and colleges apply?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible.
Can U.S. government entities apply?
Yes. Eligible applicants include several types of government entities, such as state, county, city or township, and special district governments.
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other tribal organizations are listed as eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply as the primary applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the primary applicant.
Can a non-U.S. component of a U.S. organization apply as an applicant component?
No. Non-domestic components of U.S. organizations are not eligible to apply as applicant components.
Are any types of international participation allowed?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed, meaning a U.S. applicant organization may include well-justified, discrete elements of the project performed outside the United States, subject to NIH foreign component rules and approvals.
What is a "foreign component" in the context of this opportunity?
The opportunity states that "foreign components" are allowed as defined in the NIH Grants Policy Statement, generally referring to discrete project elements conducted outside the U.S. that are scientifically necessary and appropriately justified, while keeping the applicant and leadership within an eligible U.S. entity.
What is the overall goal of using a collaborative center model for this program?
The overall goal is to integrate multiple disciplines and project elements into a single coordinated framework that can accelerate progress toward a Valley fever vaccine by coordinating expertise, resources, and translationally relevant research activities.
Where should applicants look for the most precise requirements and review expectations?
The description indicates that applicants should consult the full NOFO text, especially Section III (eligibility) and other detailed sections describing requirements, expectations, and review criteria.
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