Opportunity Information: Apply for HT9425 23 NFRP IIRA
The DoD Neurofibromatosis Research Program (NFRP) Investigator-Initiated Research Award is a competitive funding opportunity designed to support rigorous, high-impact research that can meaningfully advance neurofibromatosis (NF) science and, ultimately, improve patient care. The award is meant for investigator-driven ideas, so projects can originate from many starting points, including basic laboratory discoveries, population and epidemiology work, clinical observations drawn from direct patient care, or even well-supported anecdotal patterns that warrant deeper investigation. A key requirement is that applications must be grounded in relevant evidence: proposals need to include preliminary and/or published data directly tied to NF and to the specific research plan being proposed. While the program is open to research across essentially any phase of the research pipeline, it explicitly excludes clinical trials, so applicants need to frame their work as preclinical, translational, mechanistic, or otherwise non-trial research.
A major optional component of this opportunity is participation in the NF Open Science Initiative (NF-OSI), an effort the FY23 NFRP supports to speed progress in NF by encouraging early data access and proactive data sharing across the research community. The NF-OSI centers on the NF Data Portal (nf.synapse.org), which functions as a public repository for sharing and exploring NF-related datasets, analysis tools, resources, and publications, with a strong emphasis on raw source data rather than polished, publication-ready figures. In other words, the portal is intended for underlying data points and experimental outputs (including images and other primary artifacts) that allow independent researchers to reanalyze findings and confirm results. The program particularly encourages use of the portal for studies that generate large-scale or high-dimensional datasets, such as gene expression and other omics data (genomic variants, methylation, proteomics), drug and combination screening outputs, cellular physiology and chromatin activity datasets, imaging, kinomics, pharmacokinetics/pharmacodynamics, and data arising from clinical studies (as distinct from clinical trials).
For researchers who choose the NF-OSI option, the program outlines clear expectations around responsible, structured sharing. Data contributors are expected to follow FAIR data principles (Findable, Accessible, Interoperable, and Reusable) to improve reproducibility and reuse. The portal also supports practical realities of research timelines by allowing investigators to store data privately and then release it publicly after an embargo period, which can help balance early sharing with publication plans. Applications selecting the NF-OSI option must spell out a concrete commitment in a Data and Research Resources Sharing Plan, including milestones for when and how data or resources will be made available, and how they will remain accessible even after the award period ends. They must also explain how joining the NF-OSI will directly advance or accelerate NF research, not just comply with a sharing requirement. Importantly, for projects funded under the NF-OSI option, continued funding is tied to meeting the initiative's data submission expectations, making compliance an active condition of award performance rather than a purely aspirational goal.
Administratively, this opportunity is issued by the Department of Defense, Department of the Army, through the US Army Medical Research Acquisition Activity (USAMRAA). The funding opportunity number is HT9425 23 NFRP IIRA, categorized as discretionary funding, and it may be issued as either a grant or a cooperative agreement. The activity area is science and technology and other research and development, under CFDA 12.420. Eligibility is listed as unrestricted, meaning it is broadly open to applicants (subject to any additional eligibility language in the full announcement). The posting indicates an anticipated number of approximately five awards. The original opportunity timeline shown includes a creation date of May 22, 2023 and an original closing date of August 25, 2023. The award ceiling is listed as 0 in the provided extract, which typically signals that applicants should rely on the detailed program announcement for the actual budget limits, funding levels (including any tiering such as the referenced Level 2 funding for NF-OSI participants), and specific cost restrictions.Apply for HT9425 23 NFRP IIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis Investigator-Initiated Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 22, 2023.
- Applicants must submit their applications by Aug 25, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the DoD Neurofibromatosis Research Program (NFRP) Investigator-Initiated Research Award?
The Investigator-Initiated Research Award is a competitive funding opportunity from the DoD NFRP intended to support rigorous, high-impact research that advances neurofibromatosis (NF) science and ultimately improves patient care. It is designed for investigator-driven ideas and can support research that starts from multiple entry points across the research pipeline.
What kinds of research projects are a fit for this award?
The opportunity supports investigator-initiated projects that can originate from basic laboratory discoveries, population and epidemiology research, clinical observations from direct patient care, or well-supported anecdotal patterns that warrant deeper investigation. The program is broadly open across phases of research, as long as the work is not a clinical trial.
Are clinical trials allowed under this award?
No. The program explicitly excludes clinical trials. Applicants should frame proposed work as preclinical, translational, mechanistic, or otherwise non-trial research.
Is preliminary or published data required for the application?
Yes. Applications must be grounded in relevant evidence and must include preliminary and/or published data that are directly tied to neurofibromatosis (NF) and to the specific research plan being proposed.
How broad is the scientific scope of the award?
The scope is described as covering essentially any phase of the research pipeline, provided the project is not a clinical trial and the application includes NF-relevant evidence supporting the proposed plan.
What is the NF Open Science Initiative (NF-OSI) option?
NF-OSI is an optional component supported by the FY23 NFRP to accelerate progress in NF by encouraging early data access and proactive data sharing across the research community. Participation centers on sharing data and resources through the NF Data Portal.
What is the NF Data Portal and where is it hosted?
The NF Data Portal is a public repository for sharing and exploring NF-related datasets, analysis tools, resources, and publications. It is hosted at nf.synapse.org.
What kind of data does the NF Data Portal emphasize?
The portal places strong emphasis on raw source data rather than only polished, publication-ready figures. This includes underlying data points and experimental outputs (including images and other primary artifacts) that allow other researchers to reanalyze findings and confirm results.
What types of studies are especially encouraged to use the NF Data Portal?
The program particularly encourages use of the portal for studies generating large-scale or high-dimensional datasets, including gene expression and other omics data (genomic variants, methylation, proteomics), drug and combination screening outputs, cellular physiology and chromatin activity datasets, imaging, kinomics, pharmacokinetics/pharmacodynamics, and data arising from clinical studies (as distinct from clinical trials).
If a project selects the NF-OSI option, what data-sharing principles are expected?
Data contributors are expected to follow FAIR data principles: Findable, Accessible, Interoperable, and Reusable. The intent is to improve reproducibility and enable reuse by the broader NF research community.
Does the portal support private data storage before public release?
Yes. The portal allows investigators to store data privately and then release it publicly after an embargo period, which can help balance early sharing with publication plans.
What is required in the Data and Research Resources Sharing Plan for NF-OSI applicants?
Applications selecting the NF-OSI option must include a concrete commitment in a Data and Research Resources Sharing Plan. The plan should include milestones for when and how data and/or resources will be made available and describe how they will remain accessible even after the award period ends.
Beyond compliance, what must applicants explain about joining NF-OSI?
Applicants must explain how participating in NF-OSI will directly advance or accelerate NF research, not simply state that they will share data to meet a requirement.
Is continued funding connected to NF-OSI data submission performance?
Yes. For projects funded under the NF-OSI option, continued funding is tied to meeting the initiative's data submission expectations. Compliance functions as an active condition of award performance.
Which agency issues this funding opportunity?
The opportunity is issued by the Department of Defense, Department of the Army, through the US Army Medical Research Acquisition Activity (USAMRAA).
What is the funding opportunity number?
The funding opportunity number is HT9425 23 NFRP IIRA.
Is this opportunity a grant, a cooperative agreement, or both?
It may be issued as either a grant or a cooperative agreement.
What is the activity area and CFDA listing associated with this opportunity?
The activity area is science and technology and other research and development, under CFDA 12.420.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is broadly open to applicants, subject to any additional eligibility language that may appear in the full announcement.
How many awards are expected to be made?
The posting indicates an anticipated number of approximately five awards.
What are the key dates shown for this opportunity?
The original timeline shown includes a creation date of May 22, 2023 and an original closing date of August 25, 2023.
What is the award ceiling for this funding opportunity?
The extract lists the award ceiling as 0. This commonly indicates that budget limits and funding levels should be confirmed in the detailed program announcement, including any referenced tiering (such as Level 2 funding for NF-OSI participants) and any specific cost restrictions.
Where should applicants look for the actual budget limits and cost restrictions?
Applicants should rely on the detailed program announcement for the actual budget limits, funding levels, any tiering (including the referenced Level 2 funding for NF-OSI participants), and specific cost restrictions, since the provided extract lists an award ceiling of 0.
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| DoD Neurofibromatosis Research Academy-Scholar Award Apply for HT9425 23 NFRP NFRA SA Funding Number: HT9425 23 NFRP NFRA SA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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