Opportunity Information: Apply for PAR 17 320
The National Institutes of Health (NIH) grant opportunity "Multidisciplinary Studies of HIV/AIDS and Aging (R21)" (Funding Opportunity Number PAR-17-320) supports exploratory and developmental research that sits at the intersection of HIV and the science of aging. It is designed for early-stage, proof-of-concept, or high-impact pilot projects that can open new directions rather than fully mature, large-scale studies. The central idea is that HIV and aging are now deeply linked in real-world populations because effective antiretroviral therapy has allowed many people with HIV to live into older adulthood, while also raising new questions about how lifelong infection, long-term treatment, and social conditions shape the aging process.
The opportunity is organized around two broad objectives. First, it aims to strengthen understanding of aging itself by using HIV infection and its treatment as a lens to study biological, clinical, and socio-behavioral aspects of aging. That can include work on mechanisms of accelerated or altered aging, inflammation and immune dysfunction over time, neurocognitive changes, frailty, functional decline, or how long-term therapy interacts with age-related physiology. It also invites clinical and behavioral perspectives, such as how aging with HIV affects mental health, adherence, stigma, social isolation, caregiving, health literacy, and access to supportive services, recognizing that aging is not only biology but also lived experience shaped by environment and social context.
Second, it seeks to improve HIV testing, prevention, and treatment approaches, and to advance how clinicians and public health systems manage HIV-related comorbidities, co-infections, and complications across different populations and cultural settings by applying what is already known in aging science. This encourages projects that borrow frameworks and methods from geriatrics and gerontology to refine HIV care, such as adapting screening or prevention strategies for older adults, tailoring interventions to multimorbidity and polypharmacy, improving management of conditions that commonly cluster with HIV in later life (for example cardiovascular disease, metabolic disorders, bone health issues, renal disease, cancers, or neurocognitive impairment), and addressing co-infections and complications with an aging-informed approach. The emphasis on different populations and cultural settings signals interest in research that is attentive to diversity, health inequities, and context-specific barriers, including differences by geography, culture, and resource availability.
Applications are expected to align with the scientific priorities established by the NIH Office of AIDS Research (OAR), specifically referencing NOT-OD-15-137. In practice, that means proposed projects should fit within NIH-wide HIV/AIDS research priorities and demonstrate relevance to the strategic directions OAR outlines, such as improving prevention and treatment outcomes, addressing comorbidities, and reducing disparities. While this notice is not reproduced in the text you provided, the key takeaway for applicants is that proposals should clearly map their aims to OAR priorities and explain how the project advances HIV/AIDS research in a way that is timely and programmatically aligned.
This funding announcement uses the NIH R21 mechanism, which is intended for exploratory and developmental studies. The listed award ceiling is $200,000, reflecting the smaller, pilot-oriented scale typical of R21 awards. The opportunity is categorized as a discretionary grant in the education and health activity areas, and it is associated with multiple CFDA numbers (including 93.121, 93.242, 93.273, 93.279, 93.361, 93.393 through 93.399, 93.846, 93.853, and 93.866), reflecting the cross-institute nature of HIV and aging research and the fact that multiple NIH components may participate depending on the topic.
Eligibility is broad, which supports the multidisciplinary intent. Eligible applicants include various levels of government (state, county, city/township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, public housing authorities/Indian housing authorities, federally recognized Native American tribal governments, and Native American tribal organizations other than federally recognized tribal governments. The announcement also allows nonprofit organizations both with and without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, as well as other types of applicants. In addition, it explicitly highlights a wide set of "other eligible applicants," including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This explicit inclusion signals NIH interest in expanding participation and ensuring research is relevant to diverse communities and settings, including international contexts where HIV epidemiology, healthcare infrastructure, and aging-related needs can differ substantially.
Operationally, the administering agency is NIH, and the original closing date listed for this opportunity was September 7, 2020, with a creation date of June 23, 2017. That date information matters mainly for historical reference and for verifying whether the FOA is still active or has been reissued under a newer number. Conceptually, the opportunity is aimed at catalyzing new multidisciplinary collaborations across fields such as infectious disease, immunology, geriatrics, neurology, cardiometabolic science, behavioral health, implementation science, epidemiology, health services research, and community-engaged research. Strong applications under this FOA would typically make a clear case for innovation, explain why an R21 pilot is the right next step, and show how the project can generate data or methods that position the work for larger future studies focused on improving outcomes for people aging with HIV and on using aging science to strengthen HIV prevention and care.Apply for PAR 17 320
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.242, 93.273, 93.279, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.853, 93.866.
- This funding opportunity was created on 2017-06-23.
- Applicants must submit their applications by 2020-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PAR 17 320) also looked into and applied for these:
| Funding Opportunity |
|---|
| Multidisciplinary Studies of HIV/AIDS and Aging (R01) Apply for PAR 17 321 Funding Number: PAR 17 321 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Development of a Device to Objectively Measure Pain (R43/R44) Apply for RFA DA 18 012 Funding Number: RFA DA 18 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Development of a Device to Objectively Measure Pain (R41/R42) Apply for RFA DA 18 013 Funding Number: RFA DA 18 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Using Small Molecules and Molecular Genetics to Identify Novel Targets and Mechanisms Contributing to Tumor Immune Evasion (R01) Apply for PA 17 330 Funding Number: PA 17 330 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Discovery of Small Molecule Immunomodulators for Cancer Therapy (R01) Apply for PAR 17 331 Funding Number: PAR 17 331 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Discovery of in vivo Chemical Probes for Novel Brain Targets (R01) Apply for PAR 17 336 Funding Number: PAR 17 336 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Synthetic Biology for Engineering Applications (R01) Apply for PAR 17 334 Funding Number: PAR 17 334 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Assay development and screening for discovery of chemical probes or therapeutic agents (R01) Apply for PAR 17 438 Funding Number: PAR 17 438 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cardiovascular and Pulmonary Research on E-Cigarettes (R01) Apply for RFA HL 18 024 Funding Number: RFA HL 18 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| NINR Center of Excellence (P30) Apply for RFA NR 17 003 Funding Number: RFA NR 17 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NINR Exploratory Center (P20) Apply for RFA NR 17 002 Funding Number: RFA NR 17 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment (U01) Apply for RFA CA 17 029 Funding Number: RFA CA 17 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Pharmacogenomics of Anti-retroviral Therapy in People Who Inject Drugs (R01) Apply for RFA DA 18 014 Funding Number: RFA DA 18 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,000,000 |
| HIV-associated neuropathic pain and opioid interaction (R01) Apply for RFA DA 18 015 Funding Number: RFA DA 18 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| The Interplay of Cell Death Pathways in Cancer Cell Survival and Resistance to Therapy (R01) Apply for PA 17 440 Funding Number: PA 17 440 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Interplay of Cell Death Pathways in Cancer Cell Survival and Resistance to Therapy (R21) Apply for PA 17 449 Funding Number: PA 17 449 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Collaborative Research Network for Fusion Oncoproteins in Childhood Cancers (U54) Apply for RFA CA 17 049 Funding Number: RFA CA 17 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| Population Assessment of Tobacco and Health (PATH) Biospecimen Access (X01) Apply for PAR 17 458 Funding Number: PAR 17 458 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Lung, and Head and Neck Preneoplasias (R01) Apply for PA 17 459 Funding Number: PA 17 459 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Lung, and Head and Neck Preneoplasias (R21) Apply for PAR 17 460 Funding Number: PAR 17 460 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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