Opportunity Information: Apply for RFA EB 22 001
The BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development (UG3/UH3 Clinical Trial Not Allowed) opportunity (RFA EB 22 001) is a National Institutes of Health (NIH) funding announcement that supports team-based projects aimed at creating and proving out genuinely new, non-invasive brain imaging technologies. The central purpose is to push beyond incremental improvements and develop tools that could meaningfully change how researchers measure and map brain function and brain connectivity, with the longer-term goal of enabling new kinds of neuroscience questions to be answered. The FOA emphasizes technology development that moves from an early, promising concept to a working, validated prototype rather than purely exploratory or descriptive research.
This award uses a two-phase, milestone-driven cooperative agreement mechanism (UG3/UH3). The first phase (UG3) is designed for feasibility: applicants are expected to demonstrate that the underlying concept can work in practice and that key technical risks are addressed. By the end of UG3, the project should have clear evidence that the approach is viable, along with concrete deliverables that justify advancing to the second phase. The second phase (UH3) focuses on completing the development into a functional prototype and then validating that prototype through in vivo imaging of brain function and/or connectivity in animals or humans. The announcement is explicit that applicants should present a realistic development plan, with a timeline and measurable, tangible milestones that allow progress to be tracked and go/no-go decisions to be made between phases.
A defining feature of this FOA is its emphasis on coordinated, networked science. Funded projects are expected to become part of the BRAIN Non-Invasive Imaging Consortium, meaning awardees will not work in isolation but will be integrated into a broader, collaborative effort focused on non-invasive imaging of brain function and connectivity. Because the funding instrument is a cooperative agreement, NIH is likely to have substantial programmatic involvement compared to a standard grant, with coordination, shared goals, and alignment with consortium activities being an important part of how projects are managed and how success is measured.
The “Clinical Trial Not Allowed” designation means the proposed work cannot include clinical trials as defined by NIH policy. While the technology can be validated in humans in vivo (as the FOA anticipates), the study design must remain outside the boundaries of a clinical trial, which generally involves prospectively assigning human participants to interventions to evaluate effects on health-related outcomes. In practice, this typically steers applicants toward engineering development and performance validation, and toward human testing that is observational or focused on demonstrating technical function rather than testing clinical efficacy.
In terms of who can apply, eligibility is broad and includes many organization types: state, county, city, and special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, tribal governments other than federally recognized, and non-U.S. (foreign) organizations. This breadth reflects the program’s interest in drawing strong multidisciplinary teams from academia, industry, nonprofit research groups, and diverse institutions to tackle high-risk technical challenges.
Administratively, the opportunity is categorized as discretionary funding and uses the cooperative agreement instrument type. It falls under activity categories spanning education and health, among others, and is associated with multiple CFDA numbers (93.173, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867), reflecting the cross-cutting NIH institutes and programs that can be involved in BRAIN-related funding. The FOA was created on 2022-07-11, and the original closing date listed is 2023-01-12. The provided source data does not specify an award ceiling or the expected number of awards in the excerpt, so applicants would typically consult the full FOA for budget guidance, project period structure, and the anticipated scale of the program.
Overall, the opportunity is best understood as a structured, milestone-based push to translate ambitious, non-invasive neuroimaging ideas into working prototypes that can be demonstrated in living systems, with the added expectation that awardees will participate in a coordinated consortium aimed at accelerating progress in brain function and connectivity imaging.Apply for RFA EB 22 001
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development (UG3/UH3 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-07-11.
- Applicants must submit their applications by 2023-01-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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