Opportunity Information: Apply for PAR 16 353
Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes (R21/R33) is a National Institutes of Health (NIH) grant opportunity released under the Collaborative Research on Addiction at NIH (CRAN) initiative. The central focus is on advancing addiction treatment research in a way that is more targeted, more engaging for patients, and more reproducible across settings. In practical terms, the program is looking for projects that can generate new treatment approaches or refine existing ones and then run early-stage testing to see whether those approaches show promise for improving substance use disorder outcomes.
A defining feature of the scientific scope is its emphasis on treatments that address multiple substances rather than treating alcohol, tobacco, or other drugs in isolation. The FOA explicitly allows work spanning alcohol, tobacco, and other drug use (often grouped as ATOD). This reflects the reality that many patients present with polysubstance use and overlapping risk factors, and it encourages interventions that can be tailored to those complex, real-world patterns. The announcement also signals interest in strong methods around assessment and engagement, meaning it is not only about what the treatment is, but also about how patients are identified, recruited, retained, and supported through the care process, and how well the resulting data and findings can be reproduced or replicated.
The funding mechanism is the NIH R21/R33 phased innovation structure. The R21 phase generally supports early, exploratory work such as development, refinement, and initial feasibility or pilot testing. If predefined milestones are met, the project can transition into the R33 phase, which typically supports a more rigorous expansion of the preliminary work. In other words, the structure is meant to help investigators move from promising early concepts to a stronger, more testable package of evidence without requiring a full-scale trial right at the start. The opportunity is categorized as a discretionary grant, with an award ceiling listed at $200,000.
Eligibility is broad, spanning public sector, academic, nonprofit, and commercial organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other categories. The FOA also highlights a wide range of additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Indian/Native American Tribal Governments (other than federally recognized); eligible federal agencies; faith-based or community-based organizations; regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities (foreign organizations). Taken together, this indicates NIH is open to a variety of research-capable organizations, including those closely connected to communities disproportionately affected by addiction.
From an administrative standpoint, the opportunity number is PAR-16-353, and it is associated with CFDA numbers 93.273, 93.279, and 93.399, which correspond to NIH program areas that commonly support drug abuse, mental health, and related health research. The record lists an original closing date of 2018-01-24 and a creation date of 2016-07-01, indicating the time window when this specific posting was active.Apply for PAR 16 353
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes (R21/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279, 93.399.
- This funding opportunity was created on 2016-07-01.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the purpose of the Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes (R21/R33) opportunity?
This NIH funding opportunity supports addiction treatment research aimed at improving substance use disorder (SUD) outcomes by making treatments more targeted to patient needs, more engaging for patients, and more reproducible (replicable) across different settings. The program is intended to help generate new treatment approaches or refine existing ones, followed by early-stage testing to see whether those approaches show promise.
Which NIH initiative is this funding opportunity associated with?
It is released under the Collaborative Research on Addiction at NIH (CRAN) initiative.
What types of research projects are encouraged under this FOA?
The FOA encourages projects that develop, refine, and conduct early testing of interventions intended to improve SUD treatment outcomes. Beyond the treatment itself, it places emphasis on strong methods for assessment and engagement, such as how patients are identified, recruited, retained, and supported during care, along with approaches that improve the reproducibility or replicability of resulting data and findings.
Does the FOA focus on a single substance (like alcohol only or tobacco only), or multiple substances?
A defining feature of the scope is an emphasis on treatments that address multiple substances rather than treating alcohol, tobacco, or other drugs in isolation. The FOA explicitly allows work spanning alcohol, tobacco, and other drug use (often grouped as ATOD), reflecting real-world polysubstance use patterns.
Why does the FOA emphasize alcohol, tobacco, and other drugs (ATOD) together?
The FOA reflects the reality that many patients present with polysubstance use and overlapping risk factors. It encourages interventions that can be tailored to complex, real-world substance use patterns rather than focusing on a single substance category.
What does the FOA mean by "assessment" and "engagement"?
In this context, assessment and engagement refer to how patients are identified and assessed, and how they are recruited, retained, and supported through the treatment process. The FOA signals that these practical aspects of participating in and staying connected to care are important alongside the treatment approach itself.
What does "data replicability" or "reproducibility across settings" mean in this program?
It refers to generating data and findings that can be reproduced or replicated in different contexts and settings. The FOA highlights interest in methods and practices that strengthen confidence that results are not limited to a single site, population, or implementation scenario.
What funding mechanism does this opportunity use?
This is an NIH R21/R33 phased innovation award structure.
How do the R21 and R33 phases differ?
The R21 phase generally supports early, exploratory work such as development, refinement, and initial feasibility or pilot testing. If the project meets predefined milestones, it can transition into the R33 phase, which typically supports a more rigorous expansion of the preliminary work.
Is transition from the R21 phase to the R33 phase automatic?
No. The FOA describes a milestone-based transition: the project can move into the R33 phase if predefined milestones are met.
What is the advantage of the R21/R33 phased structure for applicants?
The phased structure is designed to help investigators move from promising early concepts to a stronger, more testable evidence package without needing to launch a full-scale trial at the very beginning.
What is the maximum award amount listed for this opportunity?
The record lists an award ceiling of $200,000.
What type of grant is this categorized as?
It is categorized as a discretionary grant.
Who is eligible to apply?
Eligibility is broad and includes public sector, academic, nonprofit, and commercial organizations. Examples listed include state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other eligible categories identified in the FOA.
Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among the eligible applicant types.
Are Tribal governments and Tribal colleges eligible to apply?
Yes. The FOA lists several Tribal-related eligible applicant types, including Indian/Native American Tribal Governments (other than federally recognized) and Tribally Controlled Colleges and Universities (TCCUs), among others.
Are minority-serving institutions eligible?
Yes. The FOA highlights eligibility for a range of minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions eligible to apply?
Yes. The FOA includes U.S. territories or possessions among eligible applicant types.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA includes non-domestic (non-U.S.) entities (foreign organizations) among the eligible applicant types.
What is the opportunity number for this FOA?
The opportunity number is PAR-16-353.
Which CFDA numbers are associated with this opportunity?
The record associates this opportunity with CFDA numbers 93.273, 93.279, and 93.399.
What do the listed CFDA numbers generally relate to?
They correspond to NIH program areas that commonly support drug abuse, mental health, and related health research.
When was this posting created, and what closing date is listed?
The record lists a creation date of 2016-07-01 and an original closing date of 2018-01-24, indicating the period when this specific posting was active.
Does this FOA require full-scale clinical trials from the start?
The description indicates the R21/R33 structure is meant to avoid requiring a full-scale trial at the start by supporting early concept development and initial testing first (R21), with more rigorous expansion later (R33) if milestones are met.
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| Funding Opportunity |
|---|
| Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes (R33) Apply for PAR 16 352 Funding Number: PAR 16 352 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Avenir Award Program for Genetics or Epigenetics of Substance Use Disorders (DP1) Apply for PAR 16 357 Funding Number: PAR 16 357 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Social Epigenomics Research Focused on Minority Health and Health Disparities (R21) Apply for PAR 16 356 Funding Number: PAR 16 356 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Social Epigenomics Research Focused on Minority Health and Health Disparities (R01) Apply for PAR 16 355 Funding Number: PAR 16 355 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| International Tobacco, and Health Research and Capacity Building Program (R01) Apply for RFA TW 16 003 Funding Number: RFA TW 16 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Research Infrastructure Development for Interdisciplinary Aging Studies (R21/R33) Apply for PAR 16 367 Funding Number: PAR 16 367 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies (R33) Apply for PAR 16 368 Funding Number: PAR 16 368 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Mechanisms of Immune Activation and Inflammation: HIV Infection, ART, and Drugs of Abuse (R01) Apply for RFA DA 17 013 Funding Number: RFA DA 17 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01) Apply for PAR 16 380 Funding Number: PAR 16 380 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chemistry Science Track Award for Rapid Transition (C/START) (R03) Apply for PAR 16 383 Funding Number: PAR 16 383 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
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| Surgical Disparities Research (R01) Apply for PAR 16 391 Funding Number: PAR 16 391 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| NIDA Program Project Grant Applications (P01) Apply for PAR 16 393 Funding Number: PAR 16 393 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analyses of Alcohol and Chronic Disease (R03) Apply for PA 16 394 Funding Number: PA 16 394 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Secondary Analyses of Alcohol and Chronic Disease (R01) Apply for PA 16 395 Funding Number: PA 16 395 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Engineering Next-Generation Human Nervous System Microphysiological Systems (R21) Apply for PAR 16 397 Funding Number: PAR 16 397 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NCI Mentored Clinical Scientist Research Career Development Award to Promote Diversity (K08) Apply for PAR 16 400 Funding Number: PAR 16 400 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Engineering Next-Generation Human Nervous System Microphysiological Systems (R01) Apply for PAR 16 398 Funding Number: PAR 16 398 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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